Relationship between 25-Hydroxyvitamin D Level and Metabolic Control and Albumin Excretion Rate in Elderly Patients with Type 2 Diabetes Mellitus

The aims of the study were 1. to investigate the frequency of 25-hydroxyvitamin D deficiency and 2. to observe the relationships between D vitamin supplementation and albumin excretion in elderly patients with type 2 diabetes mellitus (DM). The study population included 100 patients with type 2 DM treated with insulin therapy (mean age 56.1±8.8 yrs). Of 100 patients, 30 (mean age 65.4±6.4 yrs) had low 25-hydroxyvitamin (OH) D (25(OH)D) levels. Patients with low 25(OH)D levels received 50.000 unit of vitamin D3 orally every three weeks for 6 months. Albumin excretion rate was measured in patients with low level 25(OH) D before and after D vitamin supplementation. Amongst patients with deficiency; 10 (33.3%) had insufficient vitamin D levels, 19 (63.4%) had deficient levels, 1 (3.3%) had severe deficiency. There were statistically significant differences for plasma levels of A1c (p=0.003), postprandial glucose (p=0.0001), triglyceride (p=0.04), total-Cholesterol (p=0.03), LDL-Cholesterol (p=0.02), and HDLCholesterol (p=0.001) in patients with deficiency before and after D vitamin supplementation. There was high frequency of 25(OH)D deficiency in patients with type 2 diabetic patients. And also, D vitamin supplementation changed metabolic parameters such as triglyceride, totalCholesterol, LDL-Cholesterol and HDL-Cholesterol, postprandial glucose and A1c levels but not albumin excretion rate.